Maturation of the human striatal dopamine system revealed by PET and quantitative MRI

Bart Larsen; Valur Olafsson; Finnegan Calabro; Charles Laymon; Brenden Tervo-Clemmens; Elizabeth Campbell; Davneet Minhas; David Montez; Julie Price; Beatriz Luna

doi:10.1038/s41467-020-14693-3

Nature Communications (Feb 2020)

Maturation of the human striatal dopamine system revealed by PET and quantitative MRI

Bart Larsen,
Valur Olafsson,
Finnegan Calabro,
Charles Laymon,
Brenden Tervo-Clemmens,
Elizabeth Campbell,
Davneet Minhas,
David Montez,
Julie Price,
Beatriz Luna

Affiliations

Bart Larsen: Department of Psychiatry, University of Pittsburgh
Valur Olafsson: NUBIC, Northeastern University
Finnegan Calabro: Department of Psychiatry, University of Pittsburgh
Charles Laymon: Department of Bioengineering, University of Pittsburgh
Brenden Tervo-Clemmens: Department of Psychiatry, University of Pittsburgh
Elizabeth Campbell: Department of Radiology, University of Pittsburgh
Davneet Minhas: Department of Radiology, University of Pittsburgh
David Montez: Department of Psychiatry, University of Pittsburgh
Julie Price: Massachusetts General Hospital, Harvard Medical School
Beatriz Luna: Department of Psychiatry, University of Pittsburgh

DOI: https://doi.org/10.1038/s41467-020-14693-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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How the human dopamine system changes during adolescence is still unclear. Here, the authors combine PET and quantitative MRI measures to show that dopamine D2/D3 receptor availability decreases with age while presynaptic dopamine vesicular storage was developmentally stable by age 18

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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