USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS

Jinxiu Hou; Lulu Han; Ze Zhao; Huiqing Liu; Lei Zhang; Chunhong Ma; Fan Yi; Bingyu Liu; Yi Zheng; Chengjiang Gao

doi:10.1038/s41467-021-23219-4

Nature Communications (May 2021)

USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS

Jinxiu Hou,
Lulu Han,
Ze Zhao,
Huiqing Liu,
Lei Zhang,
Chunhong Ma,
Fan Yi,
Bingyu Liu,
Yi Zheng,
Chengjiang Gao

Affiliations

Jinxiu Hou: Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong University
Lulu Han: Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong University
Ze Zhao: Department of Pharmacology, School of Basic Medical Sciences, Shandong University
Huiqing Liu: Department of Pharmacology, School of Basic Medical Sciences, Shandong University
Lei Zhang: Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong University
Chunhong Ma: Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong University
Fan Yi: Department of Pharmacology, School of Basic Medical Sciences, Shandong University
Bingyu Liu: Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong University
Yi Zheng: Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong University
Chengjiang Gao: Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong University

DOI: https://doi.org/10.1038/s41467-021-23219-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Ubiquitination has an important function in the regulation of antiviral immunity involving the signalling molecule MAVS. Here the authors investigate deubiquitinating enzymes and show USP18 regulates MAVS mediated antiviral signalling through modulating the ubiquitination of MAVS via promotion of interaction between MAVS and TRIM31.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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