Pan-azole resistance in clinical Aspergillus fumigatus isolates carrying TR34/L98H from birds and mammals in Belgium
Hanne Debergh,
Roel Haesendonck,
Nadine Botteldoorn,
An Martel,
Frank Pasmans,
Claude Saegerman,
Ann Packeu
Affiliations
Hanne Debergh
Scientific Department Mycology and Aerobiology, Sciensano, 1050 Brussels, Belgium; Fundamental and Applied Research for Animal and Health (FARAH) Center, ULiège, 4000 Liège, Belgium; Corresponding author at: Scientific Department Mycology and Aerobiology, Sciensano, 1050 Brussels, Belgium
Roel Haesendonck
Zoolyx veterinary laboratory, Aalst, Belgium
Nadine Botteldoorn
Animal Health Care Flanders, Lier, Belgium
An Martel
University of Ghent, Department of Pathobiology, Pharmacology and Zoological Medicine, 9820 Merelbeke, Belgium
Frank Pasmans
University of Ghent, Department of Pathobiology, Pharmacology and Zoological Medicine, 9820 Merelbeke, Belgium
Claude Saegerman
Fundamental and Applied Research for Animal and Health (FARAH) Center, ULiège, 4000 Liège, Belgium
Ann Packeu
Scientific Department Mycology and Aerobiology, Sciensano, 1050 Brussels, Belgium; BCCM/IHEM, Mycology and Aerobiology, Sciensano, 1050 Brussels, Belgium
Aspergillosis causes significant health risks to both birds and mammals. The outcome of these infections is often poor due to delayed diagnosis and treatment failure. We investigated 152 cases of aspergillosis from birds and mammals in Belgium. Most samples originated from the taxonomic orders Artiodactyla (40.1 %) and Columbiformes (19.7 %). Five isolates (3.3 %) showed phenotypical resistance against at least one medical azole. Three of these isolates were pan-azole resistant bearing the TR34/L98H mutation. The predominance of this resistance mutation supports an environmental route for exposure and resistance selection, highlighting the importance of the One Health concept.
