Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair

Abstract

Jiacan Su, Liehu Cao, Baoqing Yu, Shaojun Song, Xinwei Liu, Zhiwei Wang, Ming LiDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, ChinaAbstract: A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400–500 µm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.Keywords: mesoporous bioglass, polyamide, composite scaffolds, biocompatibility, bone repair