Journal of Investigative Medicine High Impact Case Reports (Oct 2023)

Hematologic Abnormalities After COVID-19 Infection: A Case of Coombs-Negative Hemolytic Anemia and Thrombocytopenia

  • Alanna Glidden Siegenthaler MD,
  • Ghanshyam Ghelani MBBS,
  • Amy Brady DO,
  • Taylor Loon MBBCh,
  • Bhaskara Reddy Madhira MBBS

DOI
https://doi.org/10.1177/23247096231207687
Journal volume & issue
Vol. 11

Abstract

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The occurrence of hemolytic anemia in patients with active SARS-CoV-2 infection has been documented in medical literature. While relatively uncommon, there have been instances where this condition presents as a Coombs-negative hemolytic anemia. In this research study, we report a distinctive case of Coombs-negative hemolytic anemia and thrombocytopenia in a patient with a known history of COVID-19 infection. The patient demonstrated a favorable response to treatment involving the administration of steroids and intravenous immunoglobulin (IVIG) therapy. This case adds to the existing body of evidence regarding the hematological manifestations of SARS-CoV-2 infection, highlighting the importance of considering and managing hematological complications in patients with COVID-19.