Tomography (Sep 2022)

Prostate Cancer Biochemical Recurrence Resulted Negative on [<sup>68</sup>Ga]Ga-PSMA-11 but Positive on [<sup>18</sup>F]Fluoromethylcholine PET/CT

  • Riccardo Laudicella,
  • Flavia La Torre,
  • Valerio Davì,
  • Ludovica Crocè,
  • Demetrio Aricò,
  • Giuseppe Leonardi,
  • Simona Russo,
  • Fabio Minutoli,
  • Irene A. Burger,
  • Sergio Baldari

DOI
https://doi.org/10.3390/tomography8050205
Journal volume & issue
Vol. 8, no. 5
pp. 2471 – 2474

Abstract

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For prostate cancer (PCa) biochemical recurrence (BCR), the primarily suggested imaging technique by the European Association of Urology (EAU) guidelines is prostate-specific membrane antigen (PSMA) positron emission tomography/computer tomography (PET/CT). Indeed, the increased detection rate of PSMA PET/CT for early BCR has led to a fast and wide acceptance of this novel technology. However, PCa is a very heterogeneous disease, not always easily assessable with the highly specific PSMA PET with around 10% of cases occuring without PSMA expression. In this paper, we present the case of a patient with PCa BCR that resulted negative on [68Ga]Ga-PSMA-11 PET/CT, but positive on [18F]Fluoromethylcholine (Choline) PET/CT.

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