Factors Affecting EWS-FLI1 Activity in  Ewing's Sarcoma

David Herrero-Martin; Argyro Fourtouna; Stephan Niedan; Lucia T. Riedmann; Raphaela Schwentner; Dave N. T. Aryee

doi:10.1155/2011/352580

Sarcoma (Jan 2011)

Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma

David Herrero-Martin,
Argyro Fourtouna,
Stephan Niedan,
Lucia T. Riedmann,
Raphaela Schwentner,
Dave N. T. Aryee

Affiliations

David Herrero-Martin: Children's Cancer Research Institute, St Anna Kinderkrebsforschung, 1090 Vienna, Austria
Argyro Fourtouna: Children's Cancer Research Institute, St Anna Kinderkrebsforschung, 1090 Vienna, Austria
Stephan Niedan: Children's Cancer Research Institute, St Anna Kinderkrebsforschung, 1090 Vienna, Austria
Lucia T. Riedmann: Children's Cancer Research Institute, St Anna Kinderkrebsforschung, 1090 Vienna, Austria
Raphaela Schwentner: Children's Cancer Research Institute, St Anna Kinderkrebsforschung, 1090 Vienna, Austria
Dave N. T. Aryee: Children's Cancer Research Institute, St Anna Kinderkrebsforschung, 1090 Vienna, Austria

DOI: https://doi.org/10.1155/2011/352580
Journal volume & issue: Vol. 2011

Abstract

Read online

Ewing's sarcoma family tumors (ESFT) are characterized by specific chromosomal translocations, which give rise to EWS-ETS chimeric proteins. These aberrant transcription factors are the main pathogenic drivers of ESFT. Elucidation of the factors influencing EWS-ETS expression and/or activity will guide the development of novel therapeutic agents against this fatal disease.

Published in Sarcoma

ISSN: 1357-714X (Print); 1369-1643 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://onlinelibrary.wiley.com/journal/5805

About the journal