Fucoidan from Fucus vesiculosus Protects against Alcohol-Induced Liver Damage by Modulating Inflammatory Mediators in Mice and HepG2 Cells
Jung Dae Lim,
Sung Ryul Lee,
Taeseong Kim,
Seon-A Jang,
Se Chan Kang,
Hyun Jung Koo,
Eunsoo Sohn,
Jong Phil Bak,
Seung Namkoong,
Hyoung Kyu Kim,
In Sung Song,
Nari Kim,
Eun-Hwa Sohn,
Jin Han
Affiliations
Jung Dae Lim
Department of Herbal Medicine Resource, Kangwon National University, Gangwon-do 245-905, Korea
Sung Ryul Lee
College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea
Taeseong Kim
Department of Herbal Medicine Resource, Kangwon National University, Gangwon-do 245-905, Korea
Seon-A Jang
Department of Life Science, Gachon University, Seongnam 461-701, Korea
Se Chan Kang
Department of Life Science, Gachon University, Seongnam 461-701, Korea
Hyun Jung Koo
Department of Medicinal and Industrial Crops, Korea National College of Agriculture and Fisheries, Hwasung 445-760, Korea
Eunsoo Sohn
Division of Information Analysis Research, Korea Institute of Science and Technology Information, KISTI, Seoul 130-741, Korea
Jong Phil Bak
The Clinical Center for Bio-industry, Semyung University, Jecheon, 390-711, Korea
Seung Namkoong
Department of Physical Therapy, Kangwon National University, Gangwon-do 245-711, Korea
Hyoung Kyu Kim
College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea
In Sung Song
College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea
Nari Kim
College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea
Eun-Hwa Sohn
Department of Herbal Medicine Resource, Kangwon National University, Gangwon-do 245-905, Korea
Jin Han
College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea
Fucoidan is an l-fucose-enriched sulfated polysaccharide isolated from brown algae and marine invertebrates. In this study, we investigated the protective effect of fucoidan from Fucus vesiculosus on alcohol-induced murine liver damage. Liver injury was induced by oral administration of 25% alcohol with or without fucoidan (30 mg/kg or 60 mg/kg) for seven days. Alcohol administration increased serum aspartate aminotransferase and alanine aminotransferase levels, but these increases were suppressed by the treatment of fucoidan. Transforming growth factor beta 1 (TGF-β1), a liver fibrosis-inducing factor, was highly expressed in the alcohol-fed group and human hepatoma HepG2 cell; however, the increase in TGF-β1 expression was reduced following fucoidan administration. Treatment with fucoidan was also found to significantly reduce the production of inflammation-promoting cyclooygenase-2 and nitric oxide, while markedly increasing the expression of the hepatoprotective enzyme, hemeoxygenase-1, on murine liver and HepG2 cells. Taken together, the antifibrotic and anti-inflammatory effects of fucoidan on alcohol-induced liver damage may provide valuable insights into developing new therapeutics or interventions.
