Pharmacological Research - Modern Chinese Medicine (Dec 2023)
Therapeutic potential of morin: Special focus on cognitive dysfunction, diabetes mellitus and cancer
Abstract
Introduction: Morin is a natural polyphenol that may be derived from the leaves, fruits, stems, and branches of many different plants. It was first discovered in members of the Moraceae family. The toxicity of morin is toxicity is extremely low, and it's safe to use in long-term treatments. The current review covers several in vitro and in vivo research that investigated the health-promoting effects of morin on memory dysfunction, diabetes and cancer. Methodology: The identification of the relevant studies was done using the subsequent search terms: ''Morin'', ''Cognitive dysfunction'', ''diabetes mellitus'', ''cancer'', and other similar keywords in combination with the words botanical description, pharmacokinetics, structure, and physicochemical properties. Articles on peer reviewed journals and internationally recognized databases published in english in the period 1994–2022 were used. Results: Our findings showed that morin affects several enzymes’ activities to provide antioxidant, anti-diabetic, anti-inflammatory, antitumoral, and neuroprotective effects. Additionally, clinical research has affirmed that morin is a safe and efficient plant for human consumption. Therefore, it should be integrated into dietary habits and used as an active component in pharmaceutical formulations. Discussion: Based on distinct pieces of evidence incorporated in this study, it appears that morin holds significant promise in the development of medications and supplements for the prevention and treatment of conditions such as cancer, diabetes, and cognitive impairment-related illnesses. Conclusion: The results of this study imply that morin holds promise as a dietary flavonol for the management and alleviation of common diseases such as cognitive dysfunction, diabetes mellitus and different types of human cancers. Including morin in one's diet as a supplement appears to lower the risk of such malignancies. However, comprehensive preclinical investigations and clinical trials are essential to establish a foundation for assessing the potential effectiveness of morin in these chronic conditions.
