Genetics and Molecular Biology (Jan 2012)

Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature

  • Luize Otero,
  • Daiane Correa de Souza,
  • Rita de Cássia Tavares,
  • Bernadete Evangelho Gomes,
  • Telma França Padilha,
  • Luiz Fernando Bouzas,
  • Teresa de Souza Fernandez,
  • Eliana Abdelhay

Journal volume & issue
Vol. 35, no. 4
pp. 734 – 736

Abstract

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Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells.

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