Valorization of broiler edible byproducts: a chicken-liver hydrolysate with hepatoprotection against binge drinking

Yi-Ling Lin; Kuan-Chen Cheng; Yi-Feng Kao; Kang Wu; Jr-Wei Chen; Sasitorn Nakthong; Yi-Chen Chen

Poultry Science (Sep 2024)

Valorization of broiler edible byproducts: a chicken-liver hydrolysate with hepatoprotection against binge drinking

Yi-Ling Lin,
Kuan-Chen Cheng,
Yi-Feng Kao,
Kang Wu,
Jr-Wei Chen,
Sasitorn Nakthong,
Yi-Chen Chen

Affiliations

Yi-Ling Lin: Department of Animal Science and Technology, National Taiwan University, Taipei City 106037, Taiwan; Undergraduate and Graduate Programs of Nutrition Science, National Taiwan Normal University, Taipei City 116059, Taiwan
Kuan-Chen Cheng: Institute of Food Science and Technology, National Taiwan University, Taipei City 106319, Taiwan; Department of Optometry, Asia University, Taichung City 413305, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung City 404328, Taiwan
Yi-Feng Kao: Seafood Technology Division, Fisheries Research Institute, Ministry of Agriculture, Keelung City 202008, Taiwan
Kang Wu: Department of Animal Science and Technology, National Taiwan University, Taipei City 106037, Taiwan
Jr-Wei Chen: Department of Animal Industry, Ministry of Agriculture, Executive Yuan, Taipei City 100212, Taiwan
Sasitorn Nakthong: Department of Food Safety Innovation, Faculty of Agriculture at Kamphaeng Saen, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom Province 73140, Thailand
Yi-Chen Chen: Department of Animal Science and Technology, National Taiwan University, Taipei City 106037, Taiwan; Master Program in Global Agriculture Technology and Genomic Science, International College, National Taiwan University, Taipei City 106319, Taiwan.; Corresponding author:

Journal volume & issue: Vol. 103, no. 9
p. 104023

Abstract

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ABSTRACT: Over 10,000 metric-ton broiler livers are produced annually in Taiwan. Concerning unpleasant odor and healthy issue, broiler livers are not attractive to consumers. Although the patented chicken-liver hydrolysates (CLHs) through pepsin digestion possess several biofunctionalities, there is no study on hepatoprotection of CLH-based formula capsule (GBHP01) against binge drinking (Whiskey, 50% Alc./Vol.). GBHP01 led to an accelerated blood-alcohol clearance in rats, as evidenced by lowering blood-alcohol increment within 0 to 4 h, increasing blood-alcohol decrement within 4 to 8 h, and smaller blood alcohol concentration areas under the curve (BAC AUC) in the 8-h period (p < 0.05). The ameliorative effects of GBHP01 against binge drinking in rats over 6 wk were attributed to accelerated alcohol metabolism by further increasing alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activities while downregulating cytochrome P450 2E1 (CYP2E1) protein expression, elevating antioxidant capacity, decreasing zonula occludens-1 (ZO-1) protein decrement and serum endotoxin, and reducing inflammation related protein levels, that is, toll-like receptor 4 (TLR4) and mitogen-activated protein kinase (MAPK), and proinflammatory cytokines. The development of CLH supplements could not only enhance the added value of broiler livers through nutraceutical development but also offer a strategy to maximize the utilization of poultry processing residues, as shown in this study.

Published in Poultry Science

ISSN: 0032-5791 (Print); 1525-3171 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Agriculture: Animal culture
Website: https://www.journals.elsevier.com/poultry-science

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