Length-dependent motions of SARS-CoV-2 frameshifting RNA pseudoknot and alternative conformations suggest avenues for frameshifting suppression

Shuting Yan; Qiyao Zhu; Swati Jain; Tamar Schlick

doi:10.1038/s41467-022-31353-w

Nature Communications (Jul 2022)

Length-dependent motions of SARS-CoV-2 frameshifting RNA pseudoknot and alternative conformations suggest avenues for frameshifting suppression

Shuting Yan,
Qiyao Zhu,
Swati Jain,
Tamar Schlick

Affiliations

Shuting Yan: Department of Chemistry, New York University
Qiyao Zhu: Courant Institute of Mathematical Sciences, New York University
Swati Jain: Department of Chemistry, New York University
Tamar Schlick: Department of Chemistry, New York University

DOI: https://doi.org/10.1038/s41467-022-31353-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Modeling the SARS-CoV-2 frameshifting RNA element (FSE), a drug target against Covid-19, the authors analyze the dynamics of three FSE conformations at different lengths to propose a conformational transition pathway and describe anti-viral strategies.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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