Emerging Infectious Diseases (Jan 2021)

Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda

  • Clara Bergmann,
  • Welmoed van Loon,
  • Felix Habarugira,
  • Costanza Tacoli,
  • Julia C. Jäger,
  • Darius Savelsberg,
  • Fabian Nshimiyimana,
  • Elias Rwamugema,
  • Djibril Mbarushimana,
  • Jules Ndoli,
  • Augustin Sendegeya,
  • Claude Bayingana,
  • Frank P. Mockenhaupt

DOI
https://doi.org/10.3201/eid2701.203527
Journal volume & issue
Vol. 27, no. 1
pp. 294 – 296

Abstract

Read online

Artemisinin resistance in Plasmodium falciparum is associated with nonsynonymous mutations in the Kelch 13 (K13) propeller domain. We found that 12.1% (8/66) of clinical P. falciparum isolates from Huye district, Rwanda, exhibited K13 mutations, including R561H, a validated resistance marker. K13 mutations appear to be increasing in this region.

Keywords