A Fractional Analysis of Hyperthermia Therapy on Breast Cancer in a Porous Medium along with Radiative Microwave Heating

Abstract

Cancer is a prominent source of mortality and morbidity globally, but little is known about how it develops and spreads. Tumor cells are unable to thrive in high-temperature environments, according to recent research. Hyperthermia is the name for this therapy method. This study provides insights into hyperthermia therapy on breast cancer in the presence of a porous material with fractional derivative access when using radiative microwave heating. The mathematical model is formulated by PDE, while the time-fractional Caputo derivative is applied to make our equation more general as compared to the classical model. To produce a more efficient analysis of blood temperature distributions inside the tissues of the breast, the unsteady state is calculated by using the Laplace transform technique. The Laplace inversion is found by Durbin’s and Zakian’s algorithms. The treatment involves mild temperature hyperthermia, which causes cell death by enhancing cell sensitivity to radiation therapy and blood flow in the tumor. The variations of different parameters to control the temperate profile during therapy are discussed; we can also see how a fractional parameter makes our study more realistic for further experimental study.

Keywords

• fractional derivative
• hypothermia therapy
• breast cancer
• transfer of bioheat
• biological tissues
• radiations