Frontiers in Endocrinology (Sep 2024)

Analysis of risk factors for papillary thyroid carcinoma and the association with thyroid function indicators

  • Jianning Liu,
  • Jianning Liu,
  • Zhuoying Feng,
  • Ru Gao,
  • Ru Gao,
  • Peng Liu,
  • Peng Liu,
  • Fangang Meng,
  • Fangang Meng,
  • Lijun Fan,
  • Lijun Fan,
  • Lixiang Liu,
  • Lixiang Liu,
  • Yang Du,
  • Yang Du

DOI
https://doi.org/10.3389/fendo.2024.1429932
Journal volume & issue
Vol. 15

Abstract

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ObjectiveThis study aims to analyze the relationship between papillary thyroid carcinoma (PTC) and various factors.MethodsThe study involved two groups—PTC patients and non-PTC controls. We utilized binary logistic regression and Least Absolute Shrinkage and Selection Operator (Lasso) regression for variable selection and risk factor analysis. Correlation analysis was performed using Spearman’s rank correlation. The diagnostic value of thyroid stimulating hormone (TSH) levels for PTC was assessed using Receiver Operating Characteristic (ROC) curves.ResultsPTC patients exhibited higher body mass index (BMI) (23.71 vs. 22.66, p<0.05) and TSH levels (3.38 vs. 1.59, p<0.05). Urinary iodine concentration (UIC) was an independent predictor of PTC (OR=1.005, p<0.05). The optimal TSH threshold for PTC diagnosis was 2.4 mIU/L [The Area Under the Curve (AUC)=67.3%, specificity=71.4%, sensitivity=70.1%]. TSH levels positively correlated with BMI (r=0.593, p<0.05) and UIC (r=0.737, p<0.05).ConclusionsUIC may be an independent predictor of PTC, and TSH levels have some diagnostic value for identifying PTC.

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