Nature Communications (Sep 2018)

An OB-fold complex controls the repair pathways for DNA double-strand breaks

  • Shengxian Gao,
  • Sumin Feng,
  • Shaokai Ning,
  • Jingyan Liu,
  • Huayu Zhao,
  • Yixi Xu,
  • Jinfeng Shang,
  • Kejiao Li,
  • Qing Li,
  • Rong Guo,
  • Dongyi Xu

DOI
https://doi.org/10.1038/s41467-018-06407-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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How repair pathway selection occurs is still a matter of debate and many factors have been associated to this function. Here the authors provide insight into the role of FAM35A and C20ORF196, two REV7-interacting proteins, which are recruited at double-strand breaks to promote non-homologous end joining repair.