Communications Biology (Jul 2021)

Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif

  • Mark Ultsch,
  • Michael J. Holliday,
  • Stefan Gerhardy,
  • Paul Moran,
  • Suzie J. Scales,
  • Nidhi Gupta,
  • Francesca Oltrabella,
  • Cecilia Chiu,
  • Wayne Fairbrother,
  • Charles Eigenbrot,
  • Daniel Kirchhofer

DOI
https://doi.org/10.1038/s42003-021-02387-5
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 16

Abstract

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Mark Ultsch et al. report X-ray and NMR structures of the N-terminal domain of two closely related innate immunity proteins, ApoL1 and ApoL2. Their findings contribute to a better understanding of the ApoL immune protein family.