Frontiers in Immunology (Oct 2024)

Clinical advances and challenges associated with TCR-T cell therapy for cancer treatment

  • Jianing Li,
  • Yongsheng Zhang,
  • Tong Fu,
  • Guoli Xing,
  • Hongbo Cai,
  • Kaiqing Li,
  • Yutong Xu,
  • Ying Tong

DOI
https://doi.org/10.3389/fimmu.2024.1487782
Journal volume & issue
Vol. 15

Abstract

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BackgroundT cell receptor (TCR)-T cell therapy is an innovative form of cancer immunotherapy that genetically modifies patients’ T cells to target and destroy cancer cells. However, the current status of clinical trials of TCR-T cell therapy for the treatment of cancer remains unclear. This study aimed to comprehensively analyze the registration trials related to TCR-T cell therapy for the treatment of cancer.MethodsA comprehensive search was conducted in the Trialtrove database for all clinical trials related to TCR-T cell therapy registered by August 1, 2024. Inclusion criteria focused on trials targeting TCR-T cell therapy for oncology, and excluded observational studies and incomplete data. Statistical analysis was performed on key trial characteristics, with between-group comparisons utilizing chi-square or Fisher’s exact tests.ResultsAnalysis of 174 eligible clinical trials revealed that TCR-T cell therapy exhibits significant efficacy across various tumor types, particularly in refractory hematologic malignancies and certain solid tumors. Additionally, combining TCR-T cell therapy with other immunotherapies enhanced these anti-tumor effects.ConclusionTCR-T cell therapy holds substantial promise for cancer treatment. Future research should focus on optimizing treatment protocols, enhancing efficacy, and minimizing prices to fully realize the potential of this therapy.

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