Oxidative and Inflammatory Markers Are Higher in Full-Term Newborns Suffering Funisitis, and Higher Oxidative Markers Are Associated with Admission
Michi Kamei,
Mohamed Hamed Hussein,
Ayako Hattori,
Marwa Saleh,
Hiroki Kakita,
Ghada Abdel-Hamid Daoud,
Akio Ishiguro,
Fumihiko Namba,
Makoto Yazaki,
Haruo Goto,
Ineko Kato,
Hisanori Sobajima,
Kabe Kazuhiko,
Koichi Moriwaki,
Hajime Togari
Affiliations
Michi Kamei
Department of Pediatrics and Neonatology, Graduate School of Medical Science, Nagoya City University, Nagoya 467-8601, Japan
Mohamed Hamed Hussein
Department of Medical Research and Development, Kinjo Gakuin University, Nagoya 463-8521, Japan
Ayako Hattori
Department of Pediatrics and Neonatology, Graduate School of Medical Science, Nagoya City University, Nagoya 467-8601, Japan
Marwa Saleh
Division of Neonatology, Department of Pediatrics, Center of Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, Japan
Hiroki Kakita
Department of Perinatal and Neonatal Medicine, Aichi Medical University, Nagakute 480-1195, Japan
Division of Neonatology, Department of Pediatrics, Center of Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, Japan
Fumihiko Namba
Division of Neonatology, Department of Pediatrics, Center of Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, Japan
Makoto Yazaki
Department of Pediatrics, Hoshigaoka Maternity Hospital, Nagoya 464-0026, Japan
Haruo Goto
Department of Pediatrics, Nagoya City University West Medical Center, Nagoya 462-0033, Japan
Ineko Kato
Department of Medical Research and Development, Kinjo Gakuin University, Nagoya 463-8521, Japan
Hisanori Sobajima
Division of Neonatology, Department of Pediatrics, Center of Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, Japan
Kabe Kazuhiko
Division of Neonatology, Department of Pediatrics, Center of Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, Japan
Koichi Moriwaki
Department of Pediatrics, Center of Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, Japan
Hajime Togari
Department of Medical Research and Development, Kinjo Gakuin University, Nagoya 463-8521, Japan
The aim of this study was to assess whether oxidative and inflammatory mediators in the cord blood of newborns with funisitis and chorioamnionitis can serve as indicators of their inflammatory status, and whether there is a positive association between higher mediator levels and an increased risk of admission to the neonatal intensive care unit (NICU). This study was conducted prospectively in a neonatology department of a university hospital. In total, 52 full-term newborns were evaluated, including 17 funisitis cases, 13 chorioamnionitis cases, and 22 control newborns without funisitis or chorioamnionitis. Cord blood samples were measured for oxidative stress and inflammatory status markers. The oxidative stress markers included the total nitric oxide (NO), total hydroperoxide (TH), biological antioxidant potential (BAP), and TH/BAP ratio, comprising the oxidative stress index (OSI). Inflammatory markers included interleukin (IL)-1b, IL-6, IL-8, IL-10, tumor necrosis factor alpha (TNFα), interferon γ (IFNγ), and complement component C5a. TH, OSI, IL-1b, IL-6, and IL-8 concentrations were higher in the funisitis group than in the chorioamnionitis and control groups. C5a was higher in the funisitis and chorioamnionitis groups than in the control group. Among all enrolled newborns, 14 were admitted to the NICU. Multiple logistic regression analysis showed that elevated umbilical cord blood levels of OSI and TH were associated with a higher risk of admission to the NICU (OSI: R = 2.3, 95% CI 1.26–4.29, p = 0.007 and TH: R = 1.02, 95%CI = 1.004–1.040, p = 0.015). In conclusion, OSI and TH in cord blood from full-term newborns can provide an index of inflammatory status, and higher levels are associated with the risk of admission to the NICU and, therefore, could serve as an early indicator of inflammatory conditions in newborns.
