Holistic engineering of cell-free systems through proteome-reprogramming synthetic circuits

Luis E. Contreras-Llano; Conary Meyer; Yao Liu; Mridul Sarker; Sierin Lim; Marjorie L. Longo; Cheemeng Tan

doi:10.1038/s41467-020-16900-7

Nature Communications (Jun 2020)

Holistic engineering of cell-free systems through proteome-reprogramming synthetic circuits

Luis E. Contreras-Llano,
Conary Meyer,
Yao Liu,
Mridul Sarker,
Sierin Lim,
Marjorie L. Longo,
Cheemeng Tan

Affiliations

Luis E. Contreras-Llano: Department of Biomedical Engineering, University of California, Davis
Conary Meyer: Department of Biomedical Engineering, University of California, Davis
Yao Liu: Department of Biomedical Engineering, University of California, Davis
Mridul Sarker: School of Chemical and Biomedical Engineering, Nanyang Technological University
Sierin Lim: School of Chemical and Biomedical Engineering, Nanyang Technological University
Marjorie L. Longo: Department of Chemical Engineering, University of California, Davis
Cheemeng Tan: Department of Biomedical Engineering, University of California, Davis

DOI: https://doi.org/10.1038/s41467-020-16900-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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Synthetic biological modules can be used to reprogram host proteomes, which in turn enhance the function of the synthetic modules. The authors use this holistic synthetic biology approach to engineer a more favorable environment for cell-free protein synthesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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