Canadian Journal of Gastroenterology (Jan 1994)

Novel Targets for Anti-Inflammatory Therapy in Inflammatory Bowel Disease

  • John L Wallace

DOI
https://doi.org/10.1155/1994/765272
Journal volume & issue
Vol. 8, no. 6
pp. 373 – 378

Abstract

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Until the cause(s) of inflammatory bowel disease are identified, improvements in therapy will likely come from improved anti-inflammatory therapy or improved drug delivery systems. There are many potential targets for anti-inflammatory therapy, including the synthesis of specific inflammatory mediators. This review focuses on the potential for developing therapy aimed at three targets: nerves and neuropeptides; coagulation and thrombosis; and adhesion molecules. In each case, evidence is presented from clinical and/or experimental studies that supports the hypothesis that these are rational targets for anti-inflammatory drug development.