mBio (Feb 2021)
Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae
- Sudeshna Saha,
- Alison Coady,
- Aniruddha Sasmal,
- Kunio Kawanishi,
- Biswa Choudhury,
- Hai Yu,
- Ricardo U. Sorensen,
- Jaime Inostroza,
- Ian C. Schoenhofen,
- Xi Chen,
- Anja Münster-Kühnel,
- Chihiro Sato,
- Ken Kitajima,
- Sanjay Ram,
- Victor Nizet,
- Ajit Varki
Affiliations
- Sudeshna Saha
- ORCiD
- Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
- Alison Coady
- Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
- Aniruddha Sasmal
- Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
- Kunio Kawanishi
- ORCiD
- Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
- Biswa Choudhury
- Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
- Hai Yu
- ORCiD
- Department of Chemistry, University of California, Davis, California, USA
- Ricardo U. Sorensen
- Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
- Jaime Inostroza
- Department of Basic Sciences, School of Medicine, Universidad de La Frontera, Temuco, Chile
- Ian C. Schoenhofen
- Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Ontario, Canada
- Xi Chen
- ORCiD
- Department of Chemistry, University of California, Davis, California, USA
- Anja Münster-Kühnel
- Clinical Biochemistry, Hannover Medical School, Hannover, Germany
- Chihiro Sato
- Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan
- Ken Kitajima
- Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan
- Sanjay Ram
- Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
- Victor Nizet
- ORCiD
- Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
- Ajit Varki
- ORCiD
- Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
- DOI
- https://doi.org/10.1128/mBio.03226-20
- Journal volume & issue
-
Vol. 12,
no. 1
Abstract
All cells in vertebrates are coated with a dense array of glycans often capped with sugars called sialic acids. Sialic acids have many functions, including serving as a signal for recognition of “self” cells by the immune system, thereby guiding an appropriate immune response against foreign “nonself” and/or damaged cells.
