Detection of LMP1 protein in Breast Cancer tissue samples from Fars province hospitals

Abstract

Background and Aim: Breast cancer is the most common malignancy among women and Epstein Barr virus could be a reason to develop this cancer. The aim of this study is to evaluate the association between Epstein Barr virus and breast cancer by Immunohistochemical method in Fars province hospitals. Materials and Methods: This study was carried out in 1390-1395. 80 cases of breast cancer tissue samples were selected from formalin-fixed paraffin embedded blocks from Fars province hospitals and by immunohistochemistry method the expression of the LMP1 viral protein were examined. Data analyzed by SPSS statistical software. Results: Epstein Barr virus was not detected in the breast cancer tissues and expression of viral protein of LMP1 was not observed in any of the breast cancer specimens by Immunohistochemistry. Conclusions: The results were shown that Epstein Barr virus may not be associated with breast cancer in Fars province and further studies are needed to determine the relationship between breast cancer virus with a variety of molecular methods.

Keywords

• Epstein-Barr virus
• Breast cancer
• Immunohistochemistry
• LMP1 protein