Generation and characterization of iPSCs from a patient with obsessive–compulsive disorder, his mother with schizophrenia and his healthy father

Xu Yuan Yin; Zhen Hua Zhu; Ru Feng Chen; Jian Li; Guang Ya Zhang; Wen Long Hou; Nan Nan Zhuang; Yuan Cai; Ning Bin Dai; Fang Liu; Jing Wang; Qiu Fang Jia; Li Hui

Stem Cell Research (Feb 2023)

Generation and characterization of iPSCs from a patient with obsessive–compulsive disorder, his mother with schizophrenia and his healthy father

Xu Yuan Yin,
Zhen Hua Zhu,
Ru Feng Chen,
Jian Li,
Guang Ya Zhang,
Wen Long Hou,
Nan Nan Zhuang,
Yuan Cai,
Ning Bin Dai,
Fang Liu,
Jing Wang,
Qiu Fang Jia,
Li Hui

Affiliations

Xu Yuan Yin: Research Center of Biological Psychiatry, Suzhou Psychiatric Hospital, Suzhou Medical College, Soochow University, Suzhou 215137, Jiangsu, China
Zhen Hua Zhu: Research Center of Biological Psychiatry, Suzhou Psychiatric Hospital, Suzhou Medical College, Soochow University, Suzhou 215137, Jiangsu, China
Ru Feng Chen: Research Center of Biological Psychiatry, Suzhou Psychiatric Hospital, Suzhou Medical College, Soochow University, Suzhou 215137, Jiangsu, China
Jian Li: Changshu No. 2 People’s Hospital The Affiliated Changshu Hospital of Xuzhou Medical University, Changshu 215500, China
Guang Ya Zhang: Research Center of Biological Psychiatry, Suzhou Psychiatric Hospital, Suzhou Medical College, Soochow University, Suzhou 215137, Jiangsu, China
Wen Long Hou: Research Center of Biological Psychiatry, Suzhou Psychiatric Hospital, Suzhou Medical College, Soochow University, Suzhou 215137, Jiangsu, China
Nan Nan Zhuang: Research Center of Biological Psychiatry, Suzhou Psychiatric Hospital, Suzhou Medical College, Soochow University, Suzhou 215137, Jiangsu, China
Yuan Cai: Research Center of Biological Psychiatry, Suzhou Psychiatric Hospital, Suzhou Medical College, Soochow University, Suzhou 215137, Jiangsu, China
Ning Bin Dai: Suzhou Center of Disease Control and Prevention, Suzhou 215004, RP China
Fang Liu: Suzhou Center of Disease Control and Prevention, Suzhou 215004, RP China
Jing Wang: Research Center of Biological Psychiatry, Suzhou Psychiatric Hospital, Suzhou Medical College, Soochow University, Suzhou 215137, Jiangsu, China
Qiu Fang Jia: Research Center of Biological Psychiatry, Suzhou Psychiatric Hospital, Suzhou Medical College, Soochow University, Suzhou 215137, Jiangsu, China; Corresponding authors at: Research Center of Biological Psychiatry, Suzhou Psychiatric Hospital, Suzhou Medical College, Soochow University, No. 11 Guangqian Road, Suzhou 215137, Jiangsu Province, PR China.
Li Hui: Research Center of Biological Psychiatry, Suzhou Psychiatric Hospital, Suzhou Medical College, Soochow University, Suzhou 215137, Jiangsu, China; Corresponding authors at: Research Center of Biological Psychiatry, Suzhou Psychiatric Hospital, Suzhou Medical College, Soochow University, No. 11 Guangqian Road, Suzhou 215137, Jiangsu Province, PR China.

Journal volume & issue: Vol. 66
p. 102993

Abstract

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Schizophrenia (SCZ) and obsessive–compulsive disorder (OCD) are complex polygenic disorders with brain morphology abnormalities. The etiologies and relationship of both disorders remain elusive, and should be further investigated. Thus, induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) from an OCD patient, his mother with SCZ and his healthy father with reprograming method. All iPSCs were characterized to have normal karyotype and expression of pluripotency makers. These iPSCs will be a valuable model to elucidate the pathophysiological mechanisms and association of both diseases.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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