Nature Communications (May 2019)

Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy

  • Ramachandra M. Bhaskara,
  • Paolo Grumati,
  • Javier Garcia-Pardo,
  • Sissy Kalayil,
  • Adriana Covarrubias-Pinto,
  • Wenbo Chen,
  • Mikhail Kudryashev,
  • Ivan Dikic,
  • Gerhard Hummer

DOI
https://doi.org/10.1038/s41467-019-10345-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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FAM134B/RETREG1 is a selective ER-phagy receptor that regulates the size and shape of the endoplasmic reticulum. Here authors use molecular modeling and molecular dynamics simulations to assemble a structural model for the reticulon-homology domain of FAM134B.