Developmental exposure to non-dioxin-like polychlorinated biphenyls promotes sensory deficits and disrupts dopaminergic and GABAergic signaling in zebrafish

Abstract

Nadja Brun et al. characterize the impact of early exposure to polychlorinated biphenyls on neural development and behavior in zebrafish. Their results demonstrate that developmental exposure to these chemicals promotes sensory deficits and disrupts dopaminergic and GABAergic signaling in larval zebrafish, suggesting that these chemicals may also contribute to neurodevelopmental abnormalities in humans.