mSystems
(Oct 2021)
Using Cartesian Doubt To Build a Sequencing-Based View of Microbiology
Braden T. Tierney,
Erika Szymanski,
James R. Henriksen,
Aleksandar D. Kostic,
Chirag J. Patel
Affiliations
Braden T. Tierney
ORCiD Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA
Erika Szymanski
ORCiD Department of English, Colorado State University, Fort Collins, Colorado, USA
James R. Henriksen
ORCiD Mr. Fusion Inc., Fort Collins, Colorado, USA
Aleksandar D. Kostic
ORCiD Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, Massachusetts, USA
Chirag J. Patel
ORCiD Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA
DOI
https://doi.org/10.1128/mSystems.00574-21
Journal volume & issue
Vol. 6,
no. 5
Abstract
Read online
The technological leap of DNA sequencing generated a tension between modern metagenomics and historical microbiology. We are forcibly harmonizing the output of a modern tool with centuries of experimental knowledge derived from culture-based microbiology.
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