Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide

Abstract

An efficient Cu-catalyzed strategy for the direct C–H amination of arenes in high yields using N-hydroxyphthalimide as the amidyl radical precursor under air is reported. A possible mechanism is proposed that proceeds via a radical reaction in the presence of CuBr and triethyl phosphite.

Keywords

• amination
• copper
• n-hydroxyphthalimides
• radical reactions
• triethyl phosphite