Nature Communications (May 2021)
Co-evolution of tumor and immune cells during progression of multiple myeloma
- Ruiyang Liu,
- Qingsong Gao,
- Steven M. Foltz,
- Jared S. Fowles,
- Lijun Yao,
- Julia Tianjiao Wang,
- Song Cao,
- Hua Sun,
- Michael C. Wendl,
- Sunantha Sethuraman,
- Amila Weerasinghe,
- Michael P. Rettig,
- Erik P. Storrs,
- Christopher J. Yoon,
- Matthew A. Wyczalkowski,
- Joshua F. McMichael,
- Daniel R. Kohnen,
- Justin King,
- Scott R. Goldsmith,
- Julie O’Neal,
- Robert S. Fulton,
- Catrina C. Fronick,
- Timothy J. Ley,
- Reyka G. Jayasinghe,
- Mark A. Fiala,
- Stephen T. Oh,
- John F. DiPersio,
- Ravi Vij,
- Li Ding
Affiliations
- Ruiyang Liu
- Department of Medicine, Washington University in St. Louis
- Qingsong Gao
- Department of Medicine, Washington University in St. Louis
- Steven M. Foltz
- Department of Medicine, Washington University in St. Louis
- Jared S. Fowles
- Department of Medicine, Washington University in St. Louis
- Lijun Yao
- Department of Medicine, Washington University in St. Louis
- Julia Tianjiao Wang
- Department of Medicine, Washington University in St. Louis
- Song Cao
- Department of Medicine, Washington University in St. Louis
- Hua Sun
- Department of Medicine, Washington University in St. Louis
- Michael C. Wendl
- McDonnell Genome Institute, Washington University in St. Louis
- Sunantha Sethuraman
- Department of Medicine, Washington University in St. Louis
- Amila Weerasinghe
- Department of Medicine, Washington University in St. Louis
- Michael P. Rettig
- Department of Medicine, Washington University in St. Louis
- Erik P. Storrs
- Department of Medicine, Washington University in St. Louis
- Christopher J. Yoon
- Department of Medicine, Washington University in St. Louis
- Matthew A. Wyczalkowski
- Department of Medicine, Washington University in St. Louis
- Joshua F. McMichael
- Department of Medicine, Washington University in St. Louis
- Daniel R. Kohnen
- Department of Medicine, Washington University in St. Louis
- Justin King
- Department of Medicine, Washington University in St. Louis
- Scott R. Goldsmith
- Department of Medicine, Washington University in St. Louis
- Julie O’Neal
- Department of Medicine, Washington University in St. Louis
- Robert S. Fulton
- McDonnell Genome Institute, Washington University in St. Louis
- Catrina C. Fronick
- McDonnell Genome Institute, Washington University in St. Louis
- Timothy J. Ley
- Department of Medicine, Washington University in St. Louis
- Reyka G. Jayasinghe
- Department of Medicine, Washington University in St. Louis
- Mark A. Fiala
- Department of Medicine, Washington University in St. Louis
- Stephen T. Oh
- Department of Medicine, Washington University in St. Louis
- John F. DiPersio
- Department of Medicine, Washington University in St. Louis
- Ravi Vij
- Department of Medicine, Washington University in St. Louis
- Li Ding
- Department of Medicine, Washington University in St. Louis
- DOI
- https://doi.org/10.1038/s41467-021-22804-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Clonal evolution in multiple myeloma (MM) needs to be understood in both the tumor and its microenvironment. Here the authors perform single-cell multi-omics profiling of samples from MM patients at different stages, finding transitions in the immune cell composition throughout progression.
