Microfluidic-based nanoplatforms for cancer theranostic applications: A mini-review on recent advancements
Ali Bakhshi,
Annu Pandey,
Zelal Kharaba,
Mahtab Razlansari,
Saman Sargazi,
Razieh Behzadmehr,
Abbas Rahdar,
Ana M. Díez-Pascual,
Sonia Fathi-karkan
Affiliations
Ali Bakhshi
School of Physics, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran
Annu Pandey
Department of Fibre and Polymer Technology – Polymeric Materials, School of Chemical Science and Engineering, Teknikringen 56-58, 100 44 Stockholm, Sweden
Zelal Kharaba
College of Pharmacy, Al Ain University, 64141, Abu Dhabi, United Arab Emirates
Mahtab Razlansari
Faculty of Mathematics and Natural Sciences, Tübingen University, Tübingen, 72076, Germany
Saman Sargazi
Cellular and Molecular Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan 98167-43463, Iran
Razieh Behzadmehr
Department of Radiology, Zabol University of Medical Sciences, Zabol, Iran
Abbas Rahdar
Department of Physics, University of Zabol, Zabol 98613-35856, Iran; Corresponding authors.
Ana M. Díez-Pascual
Universidad de Alcalá, Facultad de Ciencias, Departamento de Química Analítica, Química Física e Ingeniería Química, Ctra. Madrid-Barcelona, Km. 33.6, 28805 Alcalá de Henares, Madrid, Spain; Corresponding authors.
Sonia Fathi-karkan
Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, 94531-55166 Iran; Department of Advanced Sciences and Technologies in Medicine, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd 9414974877, Iran; Corresponding authors.
Cancer is amongst the foremost causes of death worldwide, and the field of nanotechnology presents promising prospects in terms of diagnostic and therapeutic approaches. Theranostics are nanoparticles (NPs) that possess the ability to combine therapeutic and diagnostic capabilities into a single agent. Nonetheless, the synthesis, characterization, and delivery of NPs for theranostics against cancer present obstacles. By providing swift, responsive, and economical platforms for cancer detection and treatment, microfluidic systems based on nanomaterials can overcome these obstacles. A synopsis of recent developments in microfluidic-assisted theranostic nanosystems for the treatment of various malignancies is provided in this mini-review. In addition to microfluidic system-based cancer sensing methods (optical, electrochemical, mechanical, and thermal), efficacious treatment approaches (gene therapy, drug delivery, sonodynamic therapy, etc.) are examined. Further, the potential and limitations of this innovative technique are analyzed, and its potential clinical applications in the future are proposed.
