mSystems
(Oct 2021)
BiG-MAP: an Automated Pipeline To Profile Metabolic Gene Cluster Abundance and Expression in Microbiomes
Victória Pascal Andreu,
Hannah E. Augustijn,
Koen van den Berg,
Justin J. J. van der Hooft,
Michael A. Fischbach,
Marnix H. Medema
Affiliations
Victória Pascal Andreu
ORCiD Bioinformatics Group, Wageningen University, Wageningen, the Netherlands
Hannah E. Augustijn
ORCiD Bioinformatics Group, Wageningen University, Wageningen, the Netherlands
Koen van den Berg
Bioinformatics Group, Wageningen University, Wageningen, the Netherlands
Justin J. J. van der Hooft
ORCiD Bioinformatics Group, Wageningen University, Wageningen, the Netherlands
Michael A. Fischbach
ORCiD Department of Bioengineering, Stanford University, Stanford, California, USA
Marnix H. Medema
ORCiD Bioinformatics Group, Wageningen University, Wageningen, the Netherlands
DOI
https://doi.org/10.1128/mSystems.00937-21
Journal volume & issue
Vol. 6,
no. 5
Abstract
Read online
Microbes play an increasingly recognized role in determining host-associated phenotypes by producing small molecules that interact with other microorganisms or host cells. The production of these molecules is often encoded in syntenic genomic regions, also known as gene clusters.
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