Nature Communications (Dec 2020)
TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts
- Angelo L. Grauel,
- Beverly Nguyen,
- David Ruddy,
- Tyler Laszewski,
- Stephanie Schwartz,
- Jonathan Chang,
- Julie Chen,
- Michelle Piquet,
- Marc Pelletier,
- Zheng Yan,
- Nathaniel D. Kirkpatrick,
- Jincheng Wu,
- Antoine deWeck,
- Markus Riester,
- Matt Hims,
- Felipe Correa Geyer,
- Joel Wagner,
- Kenzie MacIsaac,
- James Deeds,
- Rohan Diwanji,
- Pushpa Jayaraman,
- Yenyen Yu,
- Quincey Simmons,
- Shaobu Weng,
- Alina Raza,
- Brian Minie,
- Mirek Dostalek,
- Pavitra Chikkegowda,
- Vera Ruda,
- Oleg Iartchouk,
- Naiyan Chen,
- Raphael Thierry,
- Joseph Zhou,
- Iulian Pruteanu-Malinici,
- Claire Fabre,
- Jeffrey A. Engelman,
- Glenn Dranoff,
- Viviana Cremasco
Affiliations
- Angelo L. Grauel
- Immuno-Oncology, Novartis Institutes for BioMedical Research
- Beverly Nguyen
- Immuno-Oncology, Novartis Institutes for BioMedical Research
- David Ruddy
- Oncology, Novartis Institutes for BioMedical Research
- Tyler Laszewski
- Immuno-Oncology, Novartis Institutes for BioMedical Research
- Stephanie Schwartz
- Immuno-Oncology, Novartis Institutes for BioMedical Research
- Jonathan Chang
- Immuno-Oncology, Novartis Institutes for BioMedical Research
- Julie Chen
- Oncology, Novartis Institutes for BioMedical Research
- Michelle Piquet
- Oncology, Novartis Institutes for BioMedical Research
- Marc Pelletier
- Oncology Translational Research, Novartis Institutes for BioMedical Research
- Zheng Yan
- Oncology Translational Research, Novartis Institutes for BioMedical Research
- Nathaniel D. Kirkpatrick
- Biotherapeutic and Analytical Technologies, Novartis Institutes for BioMedical Research
- Jincheng Wu
- Oncology Data Science, Novartis Institutes for BioMedical Research
- Antoine deWeck
- Oncology Data Science, Novartis Institutes for BioMedical Research
- Markus Riester
- Oncology Data Science, Novartis Institutes for BioMedical Research
- Matt Hims
- Oncology Translational Research, Novartis Institutes for BioMedical Research
- Felipe Correa Geyer
- Oncology Translational Research, Novartis Institutes for BioMedical Research
- Joel Wagner
- Oncology Data Science, Novartis Institutes for BioMedical Research
- Kenzie MacIsaac
- Oncology Data Science, Novartis Institutes for BioMedical Research
- James Deeds
- Oncology Translational Research, Novartis Institutes for BioMedical Research
- Rohan Diwanji
- Immuno-Oncology, Novartis Institutes for BioMedical Research
- Pushpa Jayaraman
- Immuno-Oncology, Novartis Institutes for BioMedical Research
- Yenyen Yu
- Oncology Translational Research, Novartis Institutes for BioMedical Research
- Quincey Simmons
- Oncology Data Science, Novartis Institutes for BioMedical Research
- Shaobu Weng
- Oncology Translational Research, Novartis Institutes for BioMedical Research
- Alina Raza
- Oncology Translational Research, Novartis Institutes for BioMedical Research
- Brian Minie
- Oncology Data Science, Novartis Institutes for BioMedical Research
- Mirek Dostalek
- PKS Oncology, Novartis Institutes for BioMedical Research
- Pavitra Chikkegowda
- Immuno-Oncology, Novartis Institutes for BioMedical Research
- Vera Ruda
- Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research
- Oleg Iartchouk
- Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research
- Naiyan Chen
- Oncology Data Science, Novartis Institutes for BioMedical Research
- Raphael Thierry
- Biotherapeutic and Analytical Technologies, Novartis Institutes for BioMedical Research
- Joseph Zhou
- Immuno-Oncology, Novartis Institutes for BioMedical Research
- Iulian Pruteanu-Malinici
- Immuno-Oncology, Novartis Institutes for BioMedical Research
- Claire Fabre
- Translational Clinical Oncology, Novartis Institutes for BioMedical Research
- Jeffrey A. Engelman
- Oncology, Novartis Institutes for BioMedical Research
- Glenn Dranoff
- Immuno-Oncology, Novartis Institutes for BioMedical Research
- Viviana Cremasco
- Immuno-Oncology, Novartis Institutes for BioMedical Research
- DOI
- https://doi.org/10.1038/s41467-020-19920-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Understanding the tumor microenviroment is important before it can be exploited therapeutically. Here, the authors use single cell sequencing to study stromal cells in mouse tumors and identify a subset of interferon-licensed cancer associated fibroblasts that appear after anti-TGFβ treatment.
