Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach

Tom G. Richardson; Daniel J. M. Crouch; Grace M. Power; Fernanda Morales-Berstein; Emma Hazelwood; Si Fang; Yoonsu Cho; Jamie R. J. Inshaw; Catherine C. Robertson; Carlo Sidore; Francesco Cucca; Steven S. Rich; John A. Todd; George Davey Smith

doi:10.1038/s41467-022-29932-y

Nature Communications (Apr 2022)

Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach

Tom G. Richardson,
Daniel J. M. Crouch,
Grace M. Power,
Fernanda Morales-Berstein,
Emma Hazelwood,
Si Fang,
Yoonsu Cho,
Jamie R. J. Inshaw,
Catherine C. Robertson,
Carlo Sidore,
Francesco Cucca,
Steven S. Rich,
John A. Todd,
George Davey Smith

Affiliations

Tom G. Richardson: MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove
Daniel J. M. Crouch: JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford
Grace M. Power: MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove
Fernanda Morales-Berstein: MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove
Emma Hazelwood: MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove
Si Fang: MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove
Yoonsu Cho: MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove
Jamie R. J. Inshaw: JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford
Catherine C. Robertson: Center for Public Health Genomics, University of Virginia
Carlo Sidore: Institute for Research in Genetics and Biomedicine (IRGB)
Francesco Cucca: Institute for Research in Genetics and Biomedicine (IRGB)
Steven S. Rich: Center for Public Health Genomics, University of Virginia
John A. Todd: JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford
George Davey Smith: MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove

DOI: https://doi.org/10.1038/s41467-022-29932-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

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The rise in type 1 diabetes is thought to be related to increased childhood obesity, but this relationship is not well understood. In this study, the authors utilize Mendelian randomization to separate the direct and indirect effects of childhood body size on risk of type 1 diabetes and 7 other immune-associated disease outcomes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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