Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration

Sharan Paul; Warunee Dansithong; Karla P. Figueroa; Daniel R. Scoles; Stefan M. Pulst

doi:10.1038/s41467-018-06041-3

Nature Communications (Sep 2018)

Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration

Sharan Paul,
Warunee Dansithong,
Karla P. Figueroa,
Daniel R. Scoles,
Stefan M. Pulst

Affiliations

Sharan Paul: Department of Neurology, University of Utah
Warunee Dansithong: Department of Neurology, University of Utah
Karla P. Figueroa: Department of Neurology, University of Utah
Daniel R. Scoles: Department of Neurology, University of Utah
Stefan M. Pulst: Department of Neurology, University of Utah

DOI: https://doi.org/10.1038/s41467-018-06041-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine repeats in the ATXN2 protein. Here the authors demonstrate that Staufen1, known to be an RNA-binding protein, interacts with ATXN2 and contributes to pathology in a mouse model of SCA2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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