A pharmacodynamic investigation into the efficacy of osteoprotegerin during aseptic inflammation

Curl Linda; Barker Christopher; Dreyer Craig; Sampson Wayne

doi:10.2478/aoj-2012-0020

Australasian Orthodontic Journal (Nov 2012)

A pharmacodynamic investigation into the efficacy of osteoprotegerin during aseptic inflammation

Curl Linda,
Barker Christopher,
Dreyer Craig,
Sampson Wayne

Affiliations

Curl Linda: 1Orthodontic Unit, School of Dentistry, The University of Adelaide, Adelaide, South Australia, Australia
Barker Christopher: 1Orthodontic Unit, School of Dentistry, The University of Adelaide, Adelaide, South Australia, Australia
Dreyer Craig: 1Orthodontic Unit, School of Dentistry, The University of Adelaide, Adelaide, South Australia, Australia
Sampson Wayne: 1Orthodontic Unit, School of Dentistry, The University of Adelaide, Adelaide, South Australia, Australia

DOI: https://doi.org/10.2478/aoj-2012-0020
Journal volume & issue: Vol. 28, no. 2
pp. 219 – 224

Abstract

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Background: Osteoprotegerin (OPG), as an osteoclast antagonist, limits mineralised tissue resorption under physiological conditions. Previous work investigating OPG in a rat periodontal ligament (PDL) ankylosis model found no inhibitory effect on osteoclasts when OPG was administered at a dosage of 2.5mg/kg.1,2

Published in Australasian Orthodontic Journal

ISSN: 2207-7480 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Medicine: Dentistry
Website: https://sciendo.com/it/journal/AOJ

About the journal