A small-molecule compound D6 overcomes EGFR-T790M-mediated resistance in non-small cell lung cancer

Xiaolong Tang; Lizhi Cheng; Guo Li; Yong-Ming Yan; Fengting Su; Dan-Ling Huang; Shuping Zhang; Zuojun Liu; Minxian Qian; Ji Li; Yong-Xian Cheng; Baohua Liu

doi:10.1038/s42003-021-02906-4

Communications Biology (Dec 2021)

A small-molecule compound D6 overcomes EGFR-T790M-mediated resistance in non-small cell lung cancer

Xiaolong Tang,
Lizhi Cheng,
Guo Li,
Yong-Ming Yan,
Fengting Su,
Dan-Ling Huang,
Shuping Zhang,
Zuojun Liu,
Minxian Qian,
Ji Li,
Yong-Xian Cheng,
Baohua Liu

Affiliations

Xiaolong Tang: Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences; Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Shenzhen University
Lizhi Cheng: Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences; Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Shenzhen University
Guo Li: Department of Dermatology, Xiangya Hospital, Central South University
Yong-Ming Yan: Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences; Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Shenzhen University
Fengting Su: Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences; Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Shenzhen University
Dan-Ling Huang: Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences; Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Shenzhen University
Shuping Zhang: Department of Dermatology, Xiangya Hospital, Central South University
Zuojun Liu: Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences; Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Shenzhen University
Minxian Qian: Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences; Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Shenzhen University
Ji Li: Department of Dermatology, Xiangya Hospital, Central South University
Yong-Xian Cheng: Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences; Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Shenzhen University
Baohua Liu: Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences; Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Shenzhen University

DOI: https://doi.org/10.1038/s42003-021-02906-4
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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Tang et al. propose the use of a small molecule compound D6 to treat EGFRTKI resistant tumors. The authors demonstrate potent and selective inhibition of NSCLC with T790M-mediated EGFR-TKI resistance through inhibiting HSP90-mediated protein–protein interaction.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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