The structural basis of the pH-homeostasis mediated by the Cl−/HCO3 − exchanger, AE2

Abstract

Cells maintain a narrow physiological pH by exchanging intracellular bicarbonate for extracellular chloride. Here, authors determine the cryo-EM structures of human anion exchanger 2 (AE2) in five major operating states and one transitional state, to collectively demonstrate the process of pH-balancing.