Journal of Clinical Medicine (Jun 2024)
Characterization and Management of Stable Coronary Artery Disease in Patients Undergoing Transcatheter Aortic Valve Implantation
- Sofia Sammartino,
- Giulia Laterra,
- Thomas Pilgrim,
- Ignacio J. Amat Santos,
- Ole De Backer,
- Won-Keun Kim,
- Henrique Barbosa Ribeiro,
- Francesco Saia,
- Matjaz Bunc,
- Didier Tchetche,
- Philippe Garot,
- Flavio Luciano Ribichini,
- Darren Mylotte,
- Francesco Burzotta,
- Yusuke Watanabe,
- Francesco Bedogni,
- Tullio Tesorio,
- Tobias Rheude,
- Gennaro Sardella,
- Marco Tocci,
- Anna Franzone,
- Roberto Valvo,
- Mikko Savontaus,
- Hendrik Wienemann,
- Italo Porto,
- Caterina Gandolfo,
- Alessandro Iadanza,
- Alessandro Santo Bortone,
- Markus Mach,
- Azeem Latib,
- Luigi Biasco,
- Maurizio Taramasso,
- Federico De Marco,
- Valentina Frittitta,
- Elena Dipietro,
- Claudia Reddavid,
- Orazio Strazzieri,
- Silvia Motta,
- Alessandro Comis,
- Chiara Melfa,
- Mariachiara Calì,
- Carmelo Sgroi,
- Mohamed Abdel-Wahab,
- Giulio Stefanini,
- Corrado Tamburino,
- Marco Barbanti,
- Giuliano Costa
Affiliations
- Sofia Sammartino
- Department of Cardiology, University of Catania, 95124 Catania, Italy
- Giulia Laterra
- Ospedale Umberto I, ASP 4 di Enna, 94100 Enna, Italy
- Thomas Pilgrim
- Bern University Hospital, Inselspital, 3010 Bern, Switzerland
- Ignacio J. Amat Santos
- Division of Cardiology, Hospital Clínico Universitario de Valladolid, 47003 Valladolid, Spain
- Ole De Backer
- The Heart Center, Rigshospitalet, Copenhagen University Hospital, 1165 Copenhagen, Denmark
- Won-Keun Kim
- Kerckhoff Heart Center, 61231 Bad Nauheim, Germany
- Henrique Barbosa Ribeiro
- Heart Institute of Sao Paulo (InCor), University of Sao Paulo, Sao Paulo 17012-901, Brazil
- Francesco Saia
- Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
- Matjaz Bunc
- Department of Cardiology, University Medical Centre Ljubljana, 1525 Ljubljana, Slovenia
- Didier Tchetche
- Clinique Pasteur, 31300 Toulouse, France
- Philippe Garot
- Institut Cardiovasculaire Paris-Sud, Hôpital Jacques Cartier, Ramsay-Santé, 91300 Massy, France
- Flavio Luciano Ribichini
- Division of Cardiology, Azienda Ospedaliera Universitaria Integrata di Verona, 37126 Verona, Italy
- Darren Mylotte
- Galway University Hospital, H91 YR71 Galway, Ireland
- Francesco Burzotta
- Department of Cardiology, IRCSS Policlinico Universitario “Agostino Gemelli”, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
- Yusuke Watanabe
- Department of Cardiology, Teikyo University School of Medicine, Tokyo 173-8605, Japan
- Francesco Bedogni
- Division of Cardiology, IRCSS Policlinico San Donato, 20097 San Donato Milanese, Italy
- Tullio Tesorio
- Clinica Montevergine, GVM Care & Research, 48033 Mercogliano, Italy
- Tobias Rheude
- German Heart Centre, 06120 Munich, Germany
- Gennaro Sardella
- Division of Cardiology, Policlinico Umberto I, 00185 Roma, Italy
- Marco Tocci
- Division of Cardiology, Policlinico Umberto I, 00185 Roma, Italy
- Anna Franzone
- Division of Cardiology, AOU Federico II, Università di Napoli, 80125 Napoli, Italy
- Roberto Valvo
- Division of Cardiology, IRCSS Policlinico San Donato, 20097 San Donato Milanese, Italy
- Mikko Savontaus
- Heart Center, Turku University Hospital, 20014 Turku, Finland
- Hendrik Wienemann
- Faculty of Medicine, University Hospital Cologne, Clinic III for Internal Medicine, University of Cologne, 50923 Cologne, Germany
- Italo Porto
- CardioThoracic and Vascular Department, San Martino Policlinico Hospital, 16132 Genova, Italy
- Caterina Gandolfo
- Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), 90127 Palermo, Italy
- Alessandro Iadanza
- Azienda Ospedaliera Universitaria Senese, UOSA Cardiologia Interventistica, Policlinico Le Scotte, 53100 Siena, Italy
- Alessandro Santo Bortone
- Division of University Cardiology, Cardiothoracic Department, Policlinico University Hospital, 70124 Bari, Italy
- Markus Mach
- Department of Cardiology, Medical University of Vienna, 1090 Vienna, Austria
- Azeem Latib
- Montefiore Medical Center, New York, NY 10461, USA
- Luigi Biasco
- Azienda Sanitaria Locale di Ciriè, Chivasso e Ivrea, ASLTO4, 10034 Chivasso, Italy
- Maurizio Taramasso
- Heart and Valve Center, University Hospital of Zurich, University of Zurich, 8006 Zurich, Switzerland
- Federico De Marco
- Centro Cardiologico Monzino, 20138 Milano, Italy
- Valentina Frittitta
- Department of Cardiology, University of Catania, 95124 Catania, Italy
- Elena Dipietro
- Department of Cardiology, University of Catania, 95124 Catania, Italy
- Claudia Reddavid
- Department of Cardiology, University of Catania, 95124 Catania, Italy
- Orazio Strazzieri
- Department of Cardiology, University of Catania, 95124 Catania, Italy
- Silvia Motta
- Department of Cardiology, University of Catania, 95124 Catania, Italy
- Alessandro Comis
- Department of Cardiology, University of Catania, 95124 Catania, Italy
- Chiara Melfa
- Department of Cardiology, University of Catania, 95124 Catania, Italy
- Mariachiara Calì
- Department of Cardiology, University of Catania, 95124 Catania, Italy
- Carmelo Sgroi
- Division of Cardiology, A.O.U. Policlinico “G. Rodolico-San Marco”, 95123 Catania, Italy
- Mohamed Abdel-Wahab
- Heart Center Leipzig, University of Leipzig, 04109 Leipzig, Germany
- Giulio Stefanini
- IRCCS Istituto Clinico Humanitas, 20089 Rozzano, Italy
- Corrado Tamburino
- Division of Cardiology, A.O.U. Policlinico “G. Rodolico-San Marco”, 95123 Catania, Italy
- Marco Barbanti
- Department of Cardiology, Università degli Studi di Enna “Kore”, Piazza dell’Università, 94100 Enna, Italy
- Giuliano Costa
- Department of Cardiology, University of Catania, 95124 Catania, Italy
- DOI
- https://doi.org/10.3390/jcm13123497
- Journal volume & issue
-
Vol. 13,
no. 12
p. 3497
Abstract
Background/Objectives: To date, data regarding the characteristics and management of obstructive, stable coronary artery disease (CAD) encountered in patients undergoing transcatheter aortic valve implantation (TAVI) are sparse. The aim of the study was to analyze granular details, treatment, and outcomes of patients undergoing TAVI with obstructive, stable CAD from real-world practice. Methods: REVASC-TAVI (Management of myocardial REVASCularization in patients undergoing Transcatheter Aortic Valve Implantation with coronary artery disease) is an investigator-initiated, multicenter registry, which collected data from patients undergoing TAVI with obstructive stable CAD found during the pre-TAVI work-up. Results: A total of 2025 patients from 30 centers worldwide with complete follow-up were included in the registry. Most patients had single-vessel CAD (56.1%). An involvement of proximal coronary tracts was detected in 62.5% of cases, with 12.0% of patients having CAD in left main (LM). Most patients received percutaneous coronary intervention (PCI) (n = 1617, 79.9%), especially those with proximal CAD (90.4%). At 2 years, the rates of all-cause death [Kaplan–Meier (KM) estimates 20.1% vs. 18.8%, plog-rank = 0.86] and of the composite of all-cause death, stroke, myocardial infarction, and rehospitalization for heart failure (KM estimates 29.7% vs. 27.5%, plog-rank = 0.82) did not differ between patients undergoing PCI and those who were not. Conclusions: Patients undergoing TAVI with obstructive CAD more commonly had a single-vessel disease and an involvement of proximal coronary tracts. They were commonly treated with PCI, with similar outcomes compared to those treated conservatively.
Keywords
