Nature Communications (Oct 2021)
ATP-citrate lyase promotes axonal transport across species
- Aviel Even,
- Giovanni Morelli,
- Silvia Turchetto,
- Michal Shilian,
- Romain Le Bail,
- Sophie Laguesse,
- Nathalie Krusy,
- Ariel Brisker,
- Alexander Brandis,
- Shani Inbar,
- Alain Chariot,
- Frédéric Saudou,
- Paula Dietrich,
- Ioannis Dragatsis,
- Bert Brone,
- Loïc Broix,
- Jean-Michel Rigo,
- Miguel Weil,
- Laurent Nguyen
Affiliations
- Aviel Even
- Laboratory for Neurodegenerative Diseases and Personalized Medicine, The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University
- Giovanni Morelli
- Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman
- Silvia Turchetto
- Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman
- Michal Shilian
- Laboratory for Neurodegenerative Diseases and Personalized Medicine, The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University
- Romain Le Bail
- Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman
- Sophie Laguesse
- Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman
- Nathalie Krusy
- Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman
- Ariel Brisker
- Laboratory for Neurodegenerative Diseases and Personalized Medicine, The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University
- Alexander Brandis
- Life Sciences Core Facilities, Weizmann Institute of Science
- Shani Inbar
- Laboratory for Neurodegenerative Diseases and Personalized Medicine, The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University
- Alain Chariot
- Laboratory of Medical Chemistry, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman
- Frédéric Saudou
- Univ. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences
- Paula Dietrich
- Department of Physiology, University of Tennessee Health Science Center
- Ioannis Dragatsis
- Department of Physiology, University of Tennessee Health Science Center
- Bert Brone
- BIOMED Research Institute
- Loïc Broix
- Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman
- Jean-Michel Rigo
- BIOMED Research Institute
- Miguel Weil
- Laboratory for Neurodegenerative Diseases and Personalized Medicine, The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University
- Laurent Nguyen
- Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman
- DOI
- https://doi.org/10.1038/s41467-021-25786-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Microtubule tracks are important for the transport of molecules within axons. Here, the authors show that ATAT1, the enzyme responsible for acetylating a-tubulin, receives acetyl groups from ATP citrate lyase whose stability is regulated by Elongator, a protein mutated in the neuronal disease Familial dysautonomia.
