Nature Communications (Oct 2018)

DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity

  • Xin-Xuan Lin,
  • Ilke Sen,
  • Georges E. Janssens,
  • Xin Zhou,
  • Bryan R. Fonslow,
  • Daniel Edgar,
  • Nicholas Stroustrup,
  • Peter Swoboda,
  • John R. Yates,
  • Gary Ruvkun,
  • Christian G. Riedel

DOI
https://doi.org/10.1038/s41467-018-06624-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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The transcription factor DAF-16/FOXO is a downstream effector of insulin/insulin-like growth factor signaling and plays an important role in stress resistance and longevity. Here, the authors show that DAF-16/FOXO can form a complex with HLH-30/TFEB to synergistically regulate transcription of target genes in response to certain stress stimuli.