Frontiers in Molecular Neuroscience (Sep 2022)
Novel therapeutic modulators of astrocytes for hydrocephalus
- Yijian Yang,
- Yijian Yang,
- Yijian Yang,
- Yijian Yang,
- Chuansen Wang,
- Chuansen Wang,
- Chuansen Wang,
- Rui Chen,
- Yuchang Wang,
- Yuchang Wang,
- Yuchang Wang,
- Changwu Tan,
- Changwu Tan,
- Changwu Tan,
- Jingping Liu,
- Jingping Liu,
- Jingping Liu,
- Qinghua Zhang,
- Qinghua Zhang,
- Gelei Xiao,
- Gelei Xiao,
- Gelei Xiao
Affiliations
- Yijian Yang
- Department of Neurosurgery, Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China
- Yijian Yang
- Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
- Yijian Yang
- Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
- Yijian Yang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Chuansen Wang
- Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
- Chuansen Wang
- Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
- Chuansen Wang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Rui Chen
- Department of Neurosurgery, Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China
- Yuchang Wang
- Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
- Yuchang Wang
- Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
- Yuchang Wang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Changwu Tan
- Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
- Changwu Tan
- Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
- Changwu Tan
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Jingping Liu
- Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
- Jingping Liu
- Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
- Jingping Liu
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Qinghua Zhang
- Department of Neurosurgery, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China
- Qinghua Zhang
- The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China
- Gelei Xiao
- Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
- Gelei Xiao
- Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
- Gelei Xiao
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- DOI
- https://doi.org/10.3389/fnmol.2022.932955
- Journal volume & issue
-
Vol. 15
Abstract
Hydrocephalus is mainly characterized by excessive production or impaired absorption of cerebrospinal fluid that causes ventricular dilation and intracranial hypertension. Astrocytes are the key response cells to inflammation in the central nervous system. In hydrocephalus, astrocytes are activated and show dual characteristics depending on the period of development of the disease. They can suppress the disease in the early stage and may aggravate it in the late stage. More evidence suggests that therapeutics targeting astrocytes may be promising for hydrocephalus. In this review, based on previous studies, we summarize different forms of hydrocephalus-induced astrocyte reactivity and the corresponding function of these responses in hydrocephalus. We also discuss the therapeutic effects of astrocyte regulation on hydrocephalus in experimental studies.
Keywords
