Nature Communications (Apr 2022)

A reversibly gated protein-transporting membrane channel made of DNA

  • Swarup Dey,
  • Adam Dorey,
  • Leeza Abraham,
  • Yongzheng Xing,
  • Irene Zhang,
  • Fei Zhang,
  • Stefan Howorka,
  • Hao Yan

DOI
https://doi.org/10.1038/s41467-022-28522-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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Artificial systems to control the transport of molecules across biomembranes can be useful for biosensing or drug delivery. Here, the authors assemble a DNA channel enabling the precisely timed, stimulus-controlled transport of functional proteins across bilayer membranes.