Helicase-like transcription factor is a RUNX1 target whose downregulation promotes genomic instability and correlates with complex cytogenetic features in acute myeloid leukemia
Chi Keung Cheng,
Natalie P. H. Chan,
Thomas S. K. Wan,
Lai Ying Lam,
Coty H. Y. Cheung,
Terry H. Y. Wong,
Rosalina K. L. Ip,
Raymond S. M. Wong,
Margaret H. L. Ng
Affiliations
Chi Keung Cheng
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Cina
Natalie P. H. Chan
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Cina
Thomas S. K. Wan
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Cina
Lai Ying Lam
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Cina
Coty H. Y. Cheung
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Cina
Terry H. Y. Wong
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Cina
Rosalina K. L. Ip
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Cina
Raymond S. M. Wong
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Cina;Sir Y. K. Pao Centre for Cancer, Prince of Wales Hospital, Hong Kong, Cina
Margaret H. L. Ng
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Cina;State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Cina
Helicase-like transcription factor is a SWI/SNF chromatin remodeling factor involved in various biological processes. However, little is known about its role in hematopoiesis. In this study, we measured helicase-like transcription factor mRNA expression in the bone marrow of 204 adult patients with de novo acute myeloid leukemia. Patients were dichotomized into low and high expression groups at the median level for clinicopathological correlations. Helicase-like transcription factor levels were dramatically reduced in the low expression patient group compared to those in the normal controls (n=40) (P