Brain Sciences (Feb 2021)
EEG Data Quality: Determinants and Impact in a Multicenter Study of Children, Adolescents, and Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)
- Anna Kaiser,
- Pascal-M. Aggensteiner,
- Martin Holtmann,
- Andreas Fallgatter,
- Marcel Romanos,
- Karina Abenova,
- Barbara Alm,
- Katja Becker,
- Manfred Döpfner,
- Thomas Ethofer,
- Christine M. Freitag,
- Julia Geissler,
- Johannes Hebebrand,
- Michael Huss,
- Thomas Jans,
- Lea Teresa Jendreizik,
- Johanna Ketter,
- Tanja Legenbauer,
- Alexandra Philipsen,
- Luise Poustka,
- Tobias Renner,
- Wolfgang Retz,
- Michael Rösler,
- Johannes Thome,
- Henrik Uebel-von Sandersleben,
- Elena von Wirth,
- Toivo Zinnow,
- Sarah Hohmann,
- Sabina Millenet,
- Nathalie E. Holz,
- Tobias Banaschewski,
- Daniel Brandeis,
- on behalf of the ESCAlife-Consortium
Affiliations
- Anna Kaiser
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany
- Pascal-M. Aggensteiner
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany
- Martin Holtmann
- LWL-University Hospital for Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, Ruhr University Bochum, 59071 Hamm, Germany
- Andreas Fallgatter
- Tübingen University Hospital for Psychiatry and Psychotherapy, 72076 Tübingen, Germany
- Marcel Romanos
- Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, 97080 Würzburg, Germany
- Karina Abenova
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany
- Barbara Alm
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany
- Katja Becker
- Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Faculty Philipps-University Marburg and University Hospital Marburg, 35039 Marburg, Germany
- Manfred Döpfner
- Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany
- Thomas Ethofer
- Tübingen University Hospital for Psychiatry and Psychotherapy, 72076 Tübingen, Germany
- Christine M. Freitag
- Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, 60323 Frankfurt am Main, Germany
- Julia Geissler
- Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, 97080 Würzburg, Germany
- Johannes Hebebrand
- Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany
- Michael Huss
- Department of Child and Adolescent Psychiatry, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany
- Thomas Jans
- Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, 97080 Würzburg, Germany
- Lea Teresa Jendreizik
- Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany
- Johanna Ketter
- Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Faculty Philipps-University Marburg and University Hospital Marburg, 35039 Marburg, Germany
- Tanja Legenbauer
- LWL-University Hospital for Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, Ruhr University Bochum, 59071 Hamm, Germany
- Alexandra Philipsen
- Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany
- Luise Poustka
- Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, 37075 Göttingen, Germany
- Tobias Renner
- Department of Child and Adolescence Psychiatry and Psychotherapy, University of Tübingen, 72076 Tübingen, Germany
- Wolfgang Retz
- Department of Psychiatry and Psychotherapy, University Medical Center Mainz, 55131 Mainz, Germany
- Michael Rösler
- Institute for Forensic Psychology and Psychiatry, Saarland University, 66424 Homburg, Germany
- Johannes Thome
- Department of Psychiatry and Psychotherapy, University Medical Center Rostock, 18055 Rostock, Germany
- Henrik Uebel-von Sandersleben
- Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, 37075 Göttingen, Germany
- Elena von Wirth
- Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany
- Toivo Zinnow
- Institute for Forensic Psychology and Psychiatry, Saarland University, 66424 Homburg, Germany
- Sarah Hohmann
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany
- Sabina Millenet
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany
- Nathalie E. Holz
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany
- Tobias Banaschewski
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany
- Daniel Brandeis
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany
- on behalf of the ESCAlife-Consortium
- DOI
- https://doi.org/10.3390/brainsci11020214
- Journal volume & issue
-
Vol. 11,
no. 2
p. 214
Abstract
Electroencephalography (EEG) represents a widely established method for assessing altered and typically developing brain function. However, systematic studies on EEG data quality, its correlates, and consequences are scarce. To address this research gap, the current study focused on the percentage of artifact-free segments after standard EEG pre-processing as a data quality index. We analyzed participant-related and methodological influences, and validity by replicating landmark EEG effects. Further, effects of data quality on spectral power analyses beyond participant-related characteristics were explored. EEG data from a multicenter ADHD-cohort (age range 6 to 45 years), and a non-ADHD school-age control group were analyzed (ntotal = 305). Resting-state data during eyes open, and eyes closed conditions, and task-related data during a cued Continuous Performance Task (CPT) were collected. After pre-processing, general linear models, and stepwise regression models were fitted to the data. We found that EEG data quality was strongly related to demographic characteristics, but not to methodological factors. We were able to replicate maturational, task, and ADHD effects reported in the EEG literature, establishing a link with EEG-landmark effects. Furthermore, we showed that poor data quality significantly increases spectral power beyond effects of maturation and symptom severity. Taken together, the current results indicate that with a careful design and systematic quality control, informative large-scale multicenter trials characterizing neurophysiological mechanisms in neurodevelopmental disorders across the lifespan are feasible. Nevertheless, results are restricted to the limitations reported. Future work will clarify predictive value.
Keywords
- electroencephalography (EEG)
- data quality
- attention-deficit/hyperactivity disorder (ADHD)
- artifacts
- multicenter study