PLoS Biology (Nov 2021)

It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling.

  • Ana Luisa Carvalho,
  • Dominique Fernandes

DOI
https://doi.org/10.1371/journal.pbio.3001448
Journal volume & issue
Vol. 19, no. 11
p. e3001448

Abstract

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Synaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to mediate synaptic scaling.