Hsp90 inhibition disrupts JAK-STAT signaling and leads to reductions in splenomegaly in patients with myeloproliferative neoplasms

• Gabriela S. Hobbs,
• Amritha Varshini Hanasoge Somasundara,
• Maria Kleppe,
• Rivka Litvin,
• Maria Arcila,
• Jihae Ahn,
• Anna Sophia McKenney,
• Kristina Knapp,
• Ryan Ptashkin,
• Howard Weinstein,
• Murk-Hein Heinemann,
• Jasmine Francis,
• Suzanne Chanel,
• Ellin Berman,
• Michael Mauro,
• Martin S. Tallman,
• Mark L. Heaney,
• Ross L. Levine,
• Raajit K. Rampal

Affiliations

Gabriela S. Hobbs

Division of Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, USA

Amritha Varshini Hanasoge Somasundara

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, USA

Maria Kleppe

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, USA

Rivka Litvin

Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, USA

Maria Arcila

Department of Pathology, Memorial Sloan Kettering Cancer Center, USA

Jihae Ahn

Driskill Graduate Program in Life Sciences, Feinberg School of Medicine, Northwestern University, USA

Anna Sophia McKenney

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, USA;Gerstner Sloan Kettering Graduate School of Biomedical Sciences, and Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, USA

Kristina Knapp

Center for Epigenetics Research Memorial Sloan Kettering Center, USA

Ryan Ptashkin

Department of Pathology, Memorial Sloan Kettering Cancer Center, USA

Howard Weinstein

Cardiology Service, Department of Medicine Memorial Sloan Kettering Cancer Center, USA

Murk-Hein Heinemann

Department of Surgery, Memorial Sloan Kettering Cancer Center, USA

Jasmine Francis

Department of Surgery, Memorial Sloan Kettering Cancer Center, USA

Suzanne Chanel

Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, USA

Ellin Berman

Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, USA

Michael Mauro

Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, USA

Martin S. Tallman

Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, USA

Mark L. Heaney

Department of Medicine, Columbia University Medical Center, USA

Ross L. Levine

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, USA;Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, USA

Raajit K. Rampal

Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, USA