The Streptomyces viridochromogenes product template domain represents an evolutionary intermediate between dehydratase and aldol cyclase of type I polyketide synthases

Yuanyuan Feng; Xu Yang; Huining Ji; Zixin Deng; Shuangjun Lin; Jianting Zheng

doi:10.1038/s42003-022-03477-8

Communications Biology (May 2022)

The Streptomyces viridochromogenes product template domain represents an evolutionary intermediate between dehydratase and aldol cyclase of type I polyketide synthases

Yuanyuan Feng,
Xu Yang,
Huining Ji,
Zixin Deng,
Shuangjun Lin,
Jianting Zheng

Affiliations

Yuanyuan Feng: State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
Xu Yang: State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
Huining Ji: State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
Zixin Deng: State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
Shuangjun Lin: State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
Jianting Zheng: State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University

DOI: https://doi.org/10.1038/s42003-022-03477-8
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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Structural analyses of a Streptomyces viridochromogenes product template (PT) domain suggests molecular and functional similarities with known fungal PTs involved in polyketide synthase activity.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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