Rituximab therapy after pediatric hematopoietic stem cell transplantation can cause prolonged B-cell impairment and increases the risk for infections - a retrospective matched cohort study

• Michael Launspach,
• Dennis Temel,
• Emily Ohlendorf,
• Felix Zirngibl,
• Bianca Materne,
• Lena Oevermann,
• Hedwig E. Deubzer,
• Anton G. Henssen,
• Annette Künkele,
• Patrick Hundsdörfer,
• Horst von Bernuth,
• Axel Pruß,
• Angelika Eggert,
• Arend von Stackelberg,
• Peter Lang,
• Johannes H. Schulte

Affiliations

Michael Launspach

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Germany; The German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany; The German Cancer Research Center (DKFZ), Heidelberg

Dennis Temel

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin

Emily Ohlendorf

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin

Felix Zirngibl

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin

Bianca Materne

Institute of Biometry and Clinical Epidemiology, Charité - Universitätsmedizin Berlin, Berlin

Lena Oevermann

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin

Hedwig E. Deubzer

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Germany; The German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany; The German Cancer Research Center (DKFZ), Heidelberg

Anton G. Henssen

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Germany; The German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany; The German Cancer Research Center (DKFZ), Heidelberg, Germany; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, Berlin

Annette Künkele

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Germany; The German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany; The German Cancer Research Center (DKFZ), Heidelberg

Patrick Hundsdörfer

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Pediatrics, Helios Klinikum Berlin-Buch, Berlin

Horst von Bernuth

Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Germany; Deparment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany; Labor Berlin - Charité Vivantes GmbH, Department of Immunology, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin

Axel Pruß

Institute of Transfusion Medicine, Charité - Universitätsmedizin Berlin, Berlin

Angelika Eggert

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Germany; The German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany; The German Cancer Research Center (DKFZ), Heidelberg

Arend von Stackelberg

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin

Peter Lang

Department of Hematology/Oncology and General Pediatrics, Children’s University Hospital, University of Tuebingen, Tuebingen

Johannes H. Schulte

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Germany; The German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany; The German Cancer Research Center (DKFZ), Heidelberg