Specialized interfaces of Smc5/6 control hinge stability and DNA association

Aaron Alt; Hung Q. Dang; Owen S. Wells; Luis M. Polo; Matt A. Smith; Grant A. McGregor; Thomas Welte; Alan R. Lehmann; Laurence H. Pearl; Johanne M. Murray; Antony W. Oliver

doi:10.1038/ncomms14011

Nature Communications (Jan 2017)

Specialized interfaces of Smc5/6 control hinge stability and DNA association

Aaron Alt,
Hung Q. Dang,
Owen S. Wells,
Luis M. Polo,
Matt A. Smith,
Grant A. McGregor,
Thomas Welte,
Alan R. Lehmann,
Laurence H. Pearl,
Johanne M. Murray,
Antony W. Oliver

Affiliations

Aaron Alt: Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Hung Q. Dang: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Owen S. Wells: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Luis M. Polo: Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Matt A. Smith: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Grant A. McGregor: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Thomas Welte: Dynamic Biosensors GmbH, Lochhamer Strasse
Alan R. Lehmann: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Laurence H. Pearl: Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Johanne M. Murray: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Antony W. Oliver: Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, School of Life Sciences, University of Sussex

DOI: https://doi.org/10.1038/ncomms14011
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

Structural Maintenance of Chromosomes (SMC) complexes maintain genome integrity by regulating the segregation of chromosomes. Here, Altet al. describe the structure of the heterodimeric Smc5/6-hinge from fission yeast and define functional features critical for Smc5/6’s cellular function.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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