Nature Communications (Oct 2020)

Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals

  • Ke Xu,
  • Boyang Li,
  • Kathleen A. McGinnis,
  • Rachel Vickers-Smith,
  • Cecilia Dao,
  • Ning Sun,
  • Rachel L. Kember,
  • Hang Zhou,
  • William C. Becker,
  • Joel Gelernter,
  • Henry R. Kranzler,
  • Hongyu Zhao,
  • Amy C. Justice,
  • VA Million Veteran Program

DOI
https://doi.org/10.1038/s41467-020-18489-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Genome-wide association studies (GWASs) for cigarette smoking have identified several hundred loci that account for a small proportion of the overall genetic risk. Here, the authors report a large GWAS for smoking trajectories and meta-analysis for smoking status, finding multiple plausible loci.